• Bradykinesia

Parkinson’s disease (PD) has a range of symptoms, such as bradykinesia, or slow movement. Patients often have trouble adjusting their body position. At the Erasmus Medical Center in Rotterdam, the Netherlands, researchers have investigated this movement disorder using a PARK15 (an atypical early-onset parkinsonism) zebrafish model and DanioVision.

Pronounced activity differences

Zebrafish larvae (96 hpf) were loaded into a 96-well plate and run through a light-dark test in the observation chamber. Pronounced differences were found: morphants were less active or showed no locomotion at all, compared to the control group.

Dopamine depletion is a key factor

Apomorphine, a typical treatment of PD, restored the level of activity completely in the morphants. However it had no effect on the control group, showing that the dopamine depletion typical of parkinsonism is a key factor leading to suppressed activity levels.  

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Find out more about this research on our blog. Read about another example of Parksinson’s research in this other case about the Familial Parkinson’s gene.

Zebrafish research with DanioVision

Larvae activity and movement patterns are basic measurements used in many studies. They can reveal information on stereotypic and epileptic behaviors, circadian rhythmicity, motor control, movement disorders, neural development, and more.

DanioVision is a complete system designed for exactly these types of experiments with zebrafish larvae, and is often used in studies related to drug development, safety pharmacology, behavioral genetics, and circadian rhythmicity.

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Zhao, T.; Zondervan-van der Linde, H.; Severijnen, L.-A.; Oostra, B.A.; Willemsen, R.; Bonifati, V. (2012). Dopaminergic neuronal loss and dopamine-dependent locomotor defects in Fbxo7-deficient zebrafish. PLOS ONE, (11), e48911.